Role of HNFA1 Gene Variants in Pancreatic Beta Cells Function and Glycaemic Control in Young Individuals with Type 1 Diabetes

The HNF1A transcription factor, implicated in the regulation of pancreatic beta cells, as well glucose and lipid metabolism, is responsible for type 3 maturity-onset diabetes young (MODY3). also involved increased susceptibility to polygenic forms diabetes, such 2 (T2D) gestational (GD), while its possible role 1 (T1D) not known. In this study, 277 children adolescents with T1D 140 healthy controls were recruited. following SNPs gene selected: rs1169286, rs1169288, rs7979478, rs2259816. Through linear or logistic regression analysis, we analyzed their association related clinical traits, insulin dose-adjusted glycated hemoglobin A1c (IDAA1c) (HbA1c). We found that rs1169286 was associated IDAA1c HbA1c values (p-value = 0.0027 p-value 0.0075, respectively), rs1169288 0.0081). No between development emerged. conclusion, our findings suggest first time variants may be a risk factor cell function glycaemic control individuals.